Reductive carboxylation supports redox homeostasis during anchorage-independent growth
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چکیده
منابع مشابه
Reductive carboxylation mediated oxidative stress defense supports anchorage independent cell growth
Background Cancer cells consume large amount of glutamine for growth and proliferation. In normal mitochondria, glutamine is converted to a-ketoglutarate, which is further oxidized through the TCA cycle [1]. Recent studies find that under certain extreme conditions, such as mitochondria dysfunction and hypoxia, cells use glutamine through reductive carboxylation (RC) to generate acetyl-CoA for ...
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Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells. In normally functioning tumour cell mitochondria, oxidative metabolism of glucoseand glutamine-derived carbon produces citrate and acetyl-coenzyme A for lipid synthesis, which is required for tumorigenesis. Yet some tumours harbour mutations in the citric acid cycle (CAC) or electron transport chain (E...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature17393